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EM 12-FS

Catalog #: 7851 Datasheet
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7851/10
7851/50
EM 12-FS | CAS No. 2839138-44-0 | Molecular Glues
1 Image
Description: Molecular glue; induces degradation of NQAT1
Alternative Names: Selective NTAQ1 degrader

Chemical Name: 3-[6-[(Fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione

Purity: ≥95%

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Biological Activity

EM12-FS is a selective N-terminal glutamine amidohydrolase 1 (NTAQ1) Degrader. In MOLT4 cells, it downregulates NTAQ1 via cereblon-mediated degradation (IC50 = 256 nM). Requires covalent His353 engagement to recruit and degrade NTAQ1.

Technical Data

M.Wt:
342.3
Formula:
C13H11FN2O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2839138-44-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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