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mRNA splicing inhibitor; antitumor
Potent and selective Cdc7 inhibitor
Potent and selective CDK7 inhibitor; induces cell cycle arrest
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest
Inhibits c-Myc-Max dimerization
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
BET bromodomain inhibitor; arrests cell cycle at G1 phase
Potent and selective mTOR inhibitor
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members
Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
Potent and selective PIP4K2A inhibitor
Potent and selective MST3 kinase binding inhibitor