Pyridostatin pentahydrochloride
Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
Purity: ≥95%
Biological Activity
Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Rodriguez et al.
Nat.Chem.Biol., 20112;8:301 -
Small-molecule-mediated G-quadruplex isolation from human cells.
M?ller et al.
Nat.Chem., 2010;2:1095 -
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
Koirala et al.
Nat.Chem., 2011;3:782
Product Datasheets
Citation for Pyridostatin pentahydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Pyridostatin pentahydrochloride include:
1 Citation: Showing 1 - 1
-
Inosine Substitutions in RNA Activate Latent G-Quadruplexes.
Authors: Sven Et al.
J Am Chem Soc 2021;143:15120-15130
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Pyridostatin pentahydrochloride
There are currently no reviews for this product. Be the first to review Pyridostatin pentahydrochloride and earn rewards!
Have you used Pyridostatin pentahydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
