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VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
Potent VEGFR, PDGFRβ and KIT inhibitor
Potent and selective PDGFR family inhibitor
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Potent VEGFR inhibitor; also inhibits other RTKs
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Selective cFMS kinase inhibitor; orally bioavailable
Dual kinase inhibitor; inhibits PI 3-K family kinases
Potent and irreversible BMX inhibitor
Potent and selective DDR1 inhibitor; orally bioavailable
Potent Mer kinase inhibitor
Zap70 inhibitor; inhibits interaction with ITAMs
Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor
Potent and selective RET inhibitor
Potent and selective FGFR inhibitor
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons