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VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
Potent VEGFR, PDGFRβ and KIT inhibitor
Potent and selective PDGFR family inhibitor
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Potent VEGFR inhibitor; also inhibits other RTKs
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Selective cFMS kinase inhibitor; orally bioavailable
Potent and selective DDR1 inhibitor; orally bioavailable
Potent Mer kinase inhibitor
Zap70 inhibitor; inhibits interaction with ITAMs
Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor
Potent and selective RET inhibitor
Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor
Potent and selective discoidin domain receptor 1/2 inhibitor
Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
Potent and selective FGFR inhibitor
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons