XL 184
Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity: ≥98%
Biological Activity
XL 184 is a potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer.
You et al.
Cancer Res., 2012;71:4758 -
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth.
Yakes et al.
Mol.Cancer Ther., 2011;10:2298
Product Datasheets
Citation for XL 184
The citations listed below are publications that use Tocris products. Selected citations for XL 184 include:
1 Citation: Showing 1 - 1
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Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.
Authors: Martín-Segura Et al.
Front Neurol 2019;10:675
FAQs
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