Home / Additional RTK Inhibitors / AZ 14145845

AZ 14145845

Catalog #: 8023 Datasheet
Catalog # Availability Size / Price Qty
8023/10
8023/50
AZ 14145845 | CAS No. 2830555-70-7 | Additional RTK Inhibitors
1 Image
Description: Dual Mer/Axl inhibitor

Chemical Name: 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine

Purity: ≥97%

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Biological Activity

AZ 14145845 is a potent, and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively). In vivo, AZ 14145845 shows dose-dependent reduction of tumor growth in the Mer and Axl kinase Ba/F3 tumor xenograft model. AZ 14145845 combined with anti-PD1 antibodies and ionizing radiation increases survival in mice with tumors derived from MC38 cells in vivo. AZ 14145845 is orally bioavailable.

Technical Data

M.Wt:
561.69
Formula:
C32H35N9O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
2830555-70-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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