7rh

Catalog #: 5860 Datasheet

Catalog #	Availability	Size / Price	Qty
5860/5

7rh | CAS No. 1429617-90-2 | Additional RTK Inhibitors

1 Image

Description: Potent and selective DDR1 inhibitor; orally bioavailable

Chemical Name: 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

Purity: ≥98%

View All Products for Additional RTK Inhibitors

Product Details

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

7rh is a potent and selective DDR1 inhibitor (IC₅₀ = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC₅₀ values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

Technical Data

M.Wt:

546.59

Formula:

C₃₀H₂₉F₃N₆O

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1429617-90-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery and optimization of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.
Gao et al.
J.Med.Chem., 2013;56:3281

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 7rh

There are currently no reviews for this product. Be the first to review 7rh and earn rewards!

Have you used 7rh?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.