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Selective inhibitor of eIF2α dephosphorylation
Potent inhibitor of ER-associated protein degradation and translocation
Dimeric Smac mimetic; potent IAP inhibitor
Potent and selective p97 ATPase (VCP) allosteric inhibitor
p97 ATPase (VCP) inhibitor
Potent and selective ASK1 inhibitor; orally bioavailable
ATP-competitive inhibitor of p97 ATPase
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase