AZD 5582 dihydrochloride
Chemical Name: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
Purity: ≥97%
Biological Activity
AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).
Hennessy et al.
J.Med.Chem., 2013;56:9897
Product Datasheets
Citations for AZD 5582 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AZD 5582 dihydrochloride include:
3 Citations: Showing 1 - 3
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A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.
Authors: Patrick J Et al.
PLoS Pathog 2023;19:e1011101
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CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.
Authors: Ying Et al.
Autophagy 2022;18:726-744
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ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.
Authors: Zinecker Et al.
Oncotarget 2017;8:106764
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