Zosuquidar trihydrochloride
Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
Purity: ≥97%
Biological Activity
Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.
Dantzig et al.
J.Pharmacol.Exp.Ther., 1999;290:854 -
Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.
Dantzig et al.
Cancer Res., 1996;56:4171
Product Datasheets
Citations for Zosuquidar trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Zosuquidar trihydrochloride include:
3 Citations: Showing 1 - 3
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Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.
Authors: Dalia Et al.
ACS Chem Biol 2022;17:2801-2816
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A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.
Authors: Troy Et al.
JCI Insight 2021;6
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Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents.
Authors: Terrance G Et al.
ACS Pharmacol Transl Sci 2019;2:402-413
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