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Taxol

Catalog #: 1097
28 Citations Datasheet
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1097/10
1097/50
Taxol | CAS No. 33069-62-4 | Microtubule Binding Compounds
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Description: Promotes assembly and inhibits disassembly of microtubules
Alternative Names: Paclitaxel

Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Purity: ≥98%

Product Details
Citations (28)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.

Technical Data

M.Wt:
853.92
Formula:
C47H51NO14
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
33069-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.

    Br. J. Cancer, 2012;107(10):1692-701.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy.
    Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, Igarashi N, Kondo R, Okajima M, Koshio J, Ichikawa K, Nozaki K, Ishikawa D, Koya T, Miura S, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I
    J Immunol, 2015;195(2):726-35.
  4. Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
    Del Nagro C, Xiao Y, Rangell L, Reichelt M, O'Brien T
    J Biol Chem, 2014;289(51):35182-92.
  5. Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
    Stephan, Sirkka B, Taber, Alexandr, Jileaeva, Ilona, Pegues, Ericka P, Sentman, Charles, Stephan, Matthias
    Nat Biotechnol, 2015;33(1):97-101.
  6. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
    McGuire et al.
    Ann.Intern.Med., 1989;111:273
  7. Taxol: a novel investigational antimicrotubule agent.
    Rowinsky et al.
    J.Natl.Cancer Inst., 1990;82:1247
  8. Taxol induces caspase-10-dependent apoptosis.
    Park et al.
    J.Biol.Chem., 2004;279:51057
  9. Characterization of the Tax. binding site on the microtubule.
    Rao et al.
    J.Biol.Chem., 1999;274:37990

Product Datasheets

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SDS
⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Taxol

The citations listed below are publications that use Tocris products. Selected citations for Taxol include:

28 Citations: Showing 1 - 10

  1. Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats.
    Authors: Villalba-Riquelme Et al.
    Br.J.Pharmacol.  2022;179:3693
  2. Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol.
    Authors: Wang Et al.
    Oncol Lett  2019;18:1402
  3. Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.
    Authors: Kyte Et al.
    J Pharmacol Exp Ther  2018;364:110
  4. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
    Authors: Wang Et al.
    Elife  2017;6
  5. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther  2017;16(6):1021
  6. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
    Authors: Ayoub
    Onco Targets Ther  2017;10:4869
  7. Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice.
    Authors: Masocha
    PeerJ  2016;4:e2702
  8. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  9. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
    Authors: Kathawala Et al.
    Oncotarget  2015;6:510
  10. Coadministration of indomet. and MinCyc attenuates established PacT.-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
    Authors: Parvathy and Masocha
    Proc Natl Acad Sci U S A  2015;5:10541
  11. Bioactivity characterization of Lactobacillus strains isolated from dairy products.
    Authors: Haghshenas Et al.
    Microbiologyopen  2015;4:803
  12. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during PacT.-induced neuropathic pain in mice.
    Authors: Masocha
    PeerJ  2015;3:e1350
  13. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel.
    Authors: Kathawala Et al.
    J Cell Sci  2015;34:115
  14. Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
    Authors: Stephan Et al.
    PLoS One  2015;33:97
  15. Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
    Authors: Vergara Et al.
    Chin J Cancer  2015;16:2174
  16. Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
    Authors: Akita Et al.
    Int J Mol Sci  2015;10:e1024396
  17. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.
    Authors: Goldmacher Et al.
    Plant Signal Behav  2015;10:e0117523
  18. Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
    Authors: Nagro Et al.
    Nat Biotechnol  2014;289:35182
  19. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
    Authors: Habu and Matsumoto
    Sci Rep  2013;2:562
  20. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
    Authors: Floyd Et al.
    EMBO J  2013;126:2845
  21. N-cadherin specifies first asymmetry in developing neurons.
    Authors: Gärtner Et al.
    Springerplus  2012;31:1893
  22. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res  2012;14:R53
  23. PacT. and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
    Authors: Lin Et al.
    Br J Cancer  2012;107:1692
  24. Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons.
    Authors: Hahm Et al.
    Brain Res  2011;1369:36
  25. Leading tip drives som. translocation via forward F-actin flow during neuronal migration.
    Authors: He Et al.
    J Neurosci  2010;30:10885
  26. Alpha-tocopheryl succinate potentiates the PacT.-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
    Authors: Lim Et al.
    Exp Mol Med  2009;41:737
  27. Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice
    Authors: Nieto Et al.
    Pain  2008;137:520
  28. Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
    Authors: Pennati Et al.
    Mol Cancer Ther  2005;4:1328

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