cis-6-Hydroxynorketamine hydrochloride
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98%
Biological Activity
cis-6-Hydroxynorketamine hydrochloride is a metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.2S,6S-enantiomer and 2R,6R-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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NMDAR inhibition-independent antidepressant actions of KA metabolites.
Zanos et al.
Nature, 2016;533:481 -
Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA.
Leung and Baillie
J.Med.Chem., 1986;29:2396
Product Datasheets
Citation for cis-6-Hydroxynorketamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for cis-6-Hydroxynorketamine hydrochloride include:
1 Citation: Showing 1 - 1
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The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like rats.
Authors: Hans-Georg Et al.
Acta Physiol (Oxf) 2019;225:e13211
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