2R,6R-Hydroxynorketamine hydrochloride
Chemical Name: (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity: ≥98%
Biological Activity
2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.2S,6S-Enantiomer and Racemate also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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NMDAR inhibition-independent antidepressant actions of KA metabolites.
Zanos et al.
Nature, 2016;533:481 -
KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells.
Singh et al.
PLoS One, 2016;11:e0149499
Product Datasheets
Citations for 2R,6R-Hydroxynorketamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 2R,6R-Hydroxynorketamine hydrochloride include:
10 Citations: Showing 1 - 10
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Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release tropomyosin-related kinase B from inhibitory control without reducing perineuronal nets enwrapping parvalbumin interneurons.
Authors: Plinio C Et al.
Eur J Neurosci 2023;57:940-950
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TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R-hydroxynorketamine.
Authors: Eero Et al.
Eur J Neurosci 2023;57:1215-1224
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Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.
Authors: Tomasz Et al.
Nat Neurosci 2023;26:1032-1041
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Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
Authors: Eero Et al.
Front Pharmacol 2022;12:755600
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Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia.
Authors: Xiangmin Et al.
Curr Biol 2020;30:3591-3603.e8
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The Ventrolateral Periaqueductal Gray Contributes to Depressive-Like Behaviors in Recovery of Inflammatory Bowel Disease Rat Model.
Authors: Jian-Hua Et al.
Front Neurosci 2020;14:254
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Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
Authors: Eero Et al.
J Biol Chem 2019;294:18150-18161
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(R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism.
Authors: Ago Et al.
Int J Neuropsychopharmacol 2019;22:665
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KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission.
Authors: Ye Et al.
Neuropharmacology 2019;157
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(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
Neuropharmacology 2018;139:1
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