2S,6S-Hydroxynorketamine hydrochloride

Catalog #: 6095
4 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
6095/10

2S,6S-Hydroxynorketamine hydrochloride | CAS No. 1430202-70-2 | AMPA Receptor Agonists

1 Image

Description: Decreases D-serine (a NMDA co-agonist); antidepressant

Chemical Name: (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Purity: ≥98%

View All Products for AMPA Receptor Agonists

Product Details

Citations (4)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC₅₀ = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

Technical Data

M.Wt:

276.16

Formula:

C₁₂H₁₄ClNO₂.HCl

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

1430202-70-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under license from the NIH, US patent 62/313,309

Other Product-Specific Information:

Background References

NMDAR inhibition-independent antidepressant actions of KA metabolites.
Zanos et al.
Nature, 2016;533:481
KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells.
Singh et al.
PLoS One, 2016;11:e0149499

Product Datasheets

COA view current batch

SDS

Citations for 2S,6S-Hydroxynorketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 2S,6S-Hydroxynorketamine hydrochloride include:

4 Citations: Showing 1 - 4

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
Authors: Eero Et al.
Front Pharmacol 2022;12:755600
(R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism.
Authors: Ago Et al.
Int J Neuropsychopharmacol 2019;22:665
KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission.
Authors: Ye Et al.
Neuropharmacology 2019;157
(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
Neuropharmacology 2018;139:1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 2S,6S-Hydroxynorketamine hydrochloride

There are currently no reviews for this product. Be the first to review 2S,6S-Hydroxynorketamine hydrochloride and earn rewards!

Have you used 2S,6S-Hydroxynorketamine hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.