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RIP1 kinase inhibitor; inhibits necroptosis
Potent RIPK2 inhibitor; orally bioavailable and cell permeable
Potent and selective RIP3 kinase inhibitor
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
Potent and metabolically stable RIP1 kinase inhibitor
Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis