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Prototypical nAChR agonist
Selective α4β2 nAChR partial agonist; orally active
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
Selective α4β2 nAChR agonist
Selective α4β2 nAChR partial agonist
Potent α4β4, α4β2 and α7 nAChR agonist
High affinity and selective α4β2 nAChR partial agonist
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
Selective α4β2 nAChR agonist