Home / Neuregulin-1 beta 1/NRG1 beta 1 / Human NRG1-beta 1/HRG1-beta 1 EGF Domain Antibody

Human NRG1-beta 1/HRG1-beta 1 EGF Domain Antibody

Catalog #: MAB3771
2 Citations Datasheet
Catalog # Availability Size / Price Qty
MAB3771-SP
MAB3771-500
MAB3771-100
Product Details
Citations (2)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human NRG1-beta 1/HRG1-beta 1 EGF Domain Antibody Summary

Species Reactivity
Human
Specificity
Detects human NRG1-beta 1 in ELISAs. Recognizes an epitope found in the EGF-like domain of NRG1‑ beta 1 (amino acids 179‑246). It also detects recombinant human SMDF (Sensory and Motor neuron-Derived Factor), but it does not recognize the EGF-like domain of human NRG1-alpha (amino acids 177‑241). The epitope is present within amino acids 213‑230 of human NRG1-beta 1. This segment is present in all NRG1 beta isoforms, GGF‑2 (glial growth factor), and SMDF, but it is absent from NRG1-alpha, NDF43, and NRG1-gamma.
Source
Monoclonal Mouse IgG1 Clone # 147705
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human NRG1-beta 1/HRG1-beta 1
Ser2-Lys246
Accession # AAA58639
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample

Human NRG1-beta 1/HRG1-beta 1 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human NRG1‑ beta 1/HRG1‑ beta 1 Extracellular Domain Biotinylated Antibody (Catalog # BAF377)

Standard: Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein (Catalog # 377-HB)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Neuregulin-1 beta 1/NRG1 beta 1

Neuregulin-1, also known as Heregulin 1, functions as a ligand for the receptor tyrosine kinases, ErbB3 and ErbB4. It exists in several different mRNA splicing variants resulting in both transmembrane and secreted forms.

Entrez Gene IDs
3084 (Human); 211323 (Mouse); 112400 (Rat)
Alternate Names
ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; neuregulin 1; Neuregulin1 beta 1; Neuregulin-1 beta 1; NRG1-IT2; SMDF

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Citations for Human NRG1-beta 1/HRG1-beta 1 EGF Domain Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy.
    Authors: Lemmens K, Doggen K, De Keulenaer GW
    Am. J. Physiol. Heart Circ. Physiol., 2010-12-24;300(3):H931-42.
    Species: Mouse, Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  2. An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.
    Authors: Sheng, Qing, Liu, Xinggang, Fleming, Eleanor, Yuan, Karen, Piao, Huiying, Chen, Jinyun, Moustafa, Zeinab, Thomas, Roman K, Greulich, Heidi, Schinzel, Anna, Zaghlul, Sara, Batt, David, Ettenberg, Seth, Meyerson, Matthew, Schoeberl, Birgit, Kung, Andrew L, Hahn, William, Drapkin, Ronny, Livingston, David M, Liu, Joyce F
    Cancer Cell, 2010-03-16;17(3):298-310.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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