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WIC1

Catalog #: 7580 Datasheet
Catalog # Availability Size / Price Qty
7580/10
7580/50
WIC1 | CAS No. 943083-58-7 | beta-Catenin
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Description: Inhibitor of Wnt/β-catenin signaling

Chemical Name: N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide

Purity: ≥98%

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Biological Activity

WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-cateninY489 and Tp63 expression.

Technical Data

M.Wt:
377.44
Formula:
C22H23N3O3
Solubility:
Soluble to 2 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
943083-58-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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