TAT-Gap19(I130A)
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Description: Control peptide for TAT-Gap19
Purity: ≥95%
Biological Activity
TAT-Gap19(I130A) is a control peptide for TAT-Gap19 (Cat. No. 6227), a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.Technical Data
M.Wt:
2661.2
Formula:
C116H206N46O26
Sequence:
YGRKKRRQRRRKQAEIKKFK
Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.
Wang et al.
Basic Res.Cardiol., 2013;108:309
Product Datasheets
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