TAT-Gap19
Purity: ≥95%
Biological Activity
TAT-Gap19 is a Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara et al.
Front.Cell.Neurosci., 2014;8:1 -
Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.
Freitas-Andrade and Naus
Neuroscience., 2016;323:207
Product Datasheets
Citations for TAT-Gap19
The citations listed below are publications that use Tocris products. Selected citations for TAT-Gap19 include:
2 Citations: Showing 1 - 2
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Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.
Authors: Wei Et al.
J Neuroinflammation 2020;17:322
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Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins.
Authors: Matthias M Et al.
Development 2020;147
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