SJ 3149 New
Chemical Name: 3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: ≥98%
Biological Activity
SJ 3149 is a potent and selective CK1α molecular glue Degrader (DC50 = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1α protein (DC50 = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC50 = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo, SJ 3149 degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
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