(S)-(-)-HA-966

Biological Activity

R-enantiomer also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Responses of rat substantia nigra DA-containing neurones to (-)-HA-966 in vitro.
   Grobaski et al.
   Br.J.Pharmacol., 1997;120:575
3. (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra DA neurons through a non-N-MthD.-aspartate receptor mediated mechanism.
   Shepard and Lehmann
   J.Pharmacol.Exp.Ther., 1992;261:387
4. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-MthD.-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative.
   Singh et al.
   Proc.Natl.Acad.Sci.U.S.A., 1990;87:347

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