(R)-(+)-HA-966
Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
Purity: ≥98%
Biological Activity
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.S-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons.
Kemp and Priestley
Mol.Pharmacol., 1991;39:666 -
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex.
Pullan et al.
J.Neurochem., 1990;55:1346 -
Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Pullan et al.
Eur.J.Pharmacol., 1991;208:25
Product Datasheets
Citation for (R)-(+)-HA-966
The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:
1 Citation: Showing 1 - 1
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σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias.
Authors: Paquette Et al.
Elife 2008;19:111
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