(R)-(+)-8-Hydroxy-DPAT hydrobromide

Catalog #: 1080
4 Citations Datasheet

Discontinued Product

1080 has been discontinued.

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(R)-(+)-8-Hydroxy-DPAT hydrobromide | CAS No. 78095-19-9 | 5-HT1 Receptor Agonists

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Description: Selective 5-HT1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)

Chemical Name: (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide

Purity: ≥98%

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Product Details

Citations (4)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT_1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.

Racemate and 7-Hydroxy Isomer also available.

Technical Data

M.Wt:

328.29

Formula:

C₁₆H₂₅NO.HBr

Solubility:

Soluble to 75 mM in water and to 75 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at +4°C

CAS No:

78095-19-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT_1A receptors in the brain.
Bjork et al.
J.Med.Chem., 1989;32:779
Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine_1A receptors that are negatively coupled to adenylate cyclase.
Corrfield et al.
Mol.Pharmacol., 1991;39:780
Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats.
Yoshitake and Kehr
Life Sci., 2004;74:2865

Product Datasheets

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Citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:

4 Citations: Showing 1 - 4

5-HT1A Receptor Function Makes Wound Healing a Happier Process.
Authors: Sadiq Et al.
Front Pharmacol 2019;9:1406
SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
Authors: Cassilly Et al.
Psychopharmacology (Berl) 2016;11:e0154932
The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
Authors: Wierońska Et al.
Oncoscience 2015;232:259
Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by cital. and escital.
Authors: Rossi Et al.
Eur J Pharmacol 2008;583:103

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