7-Hydroxy-DPAT hydrobromide
Chemical Name: (±)-7-Hydroxy-2-dipropylaminotetralin hydrobromide
Purity: ≥99%
Biological Activity
7-Hydroxy-DPAT hydrobromide is a D3 dopamine receptor agonist (Ki values are ~ 1, 10, 650 and ~ 5000 nM for D3, D2, D4 and D1 receptors respectively).8-Hydroxy Isomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D
J Immunol, 2014;193(6):2792-800. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Behavioural effects of the D3 DA receptor agonist 7-OH-DPAT in relation to other D2-like agonists.
Daly and Waddington
Neuropharmacology, 1993;32:509 -
Aminotetralin drugs and D3 receptor fuctions.
Levesque
Biochem.Pharmacol., 1996;52:511 -
Identification, characterization, and localization of the DA D3 receptor in rat brain using [3H]-7-hydroxy-N,N-di-n-propyl-2-aminotetralin.
Levesque et al.
Proc.Natl.Acad.Sci.U.S.A., 1992;89:8155 -
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
Product Datasheets
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