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PSC 833

Catalog #: 4042
8 Citations Datasheet
Catalog # Availability Size / Price Qty
4042/1
PSC 833 | CAS No. 121584-18-7 | Multidrug Transporter Inhibitors
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Description: Inhibitor of P-gp-mediated MDR
Alternative Names: Valspodar

Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

Purity: ≥98%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Technical Data

M.Wt:
1214.62
Formula:
C63H111N11O12
Solubility:
Soluble to 2 mg/ml in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
121584-18-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Mechanisms of Pinometostat (EPZ-5676) Treatment Emergent Resistance in MLL Rearranged Leukemia
    CT Campbell, JN Haladyna, DA Drubin, TM Thomson, MJ Maria, T Yamauchi, NJ Waters, EJ Olhava, RM Pollock, JJ Smith, RA Copeland, SJ Blakemore, KM Bernt, SR Daigle
    Mol. Cancer Ther., 2017;0(0):.
  2. Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo.
    Song et al.
    J.Pharmacol.Exp.Ther., 1998;287:963
  3. Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody.
    Goda et al.
    J.Pharmacol.Exp.Ther., 2007;320:81
  4. Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
    Shen et al.
    J.Pharmacol.Exp.Ther., 2008;324:95
  5. Dynamic assessment of mitoxan. resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells.
    Shen et al.
    J.Pharmacol.Exp.Ther., 2009;330:423

Product Datasheets

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Citations for PSC 833

The citations listed below are publications that use Tocris products. Selected citations for PSC 833 include:

8 Citations: Showing 1 - 8

  1. Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.
    Authors: Michael Et al.
    Nat Genet  2022;54:1690-1701
  2. Biomaterial screening of protein coatings and peptide additives: towards a simple synthetic mimic of a complex natural coating for a bio-artificial kidney.
    Authors: Mark C Et al.
    Biomater Sci  2021;9:2209-2220
  3. Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.
    Authors: Jos Et al.
    J Pharm Sci  2021;110:1601-1614
  4. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
    Authors: Kim and Bynoe
    J Clin Invest  2016;126:1717
  5. Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism.
    Authors: Slosky Et al.
    Mol Pharmacol  2013;84:774
  6. Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model.
    Authors: Ong Et al.
    Antimicrob Agents Chemother  2013;57:2535
  7. Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-OE involves differential regulation of plasma membrane associated estrogen receptors.
    Authors: Elbaradie Et al.
    Sci Rep  2013;1833:1165
  8. Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells.
    Authors: Lipka Et al.
    PLoS One  2012;7:e40853

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