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PRIMA-1MET

Catalog #: 3710
3 Citations Datasheet
Catalog # Availability Size / Price Qty
3710/10
PRIMA-1MET | CAS No. 5291-32-7 | Additional p53-related Compounds
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Description: Restores mutant p53 activity
Alternative Names: APR-246

Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Technical Data

M.Wt:
199.25
Formula:
C10H17NO3
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
5291-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
    Aryee, D N T, Niedan, S, Ban, J, Schwentner, R, Muehlbacher, K, Kauer, M, Kofler, R, Kovar, H
    Br J Cancer, 2013;109(10):2696-704.
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Robinson T, Liu J, Vizeacoumar F, Sun T, Maclean N, Egan S, Schimmer A, Datti A, Zacksenhaus E
    PLoS ONE, 2013;8(11):e78641.
  3. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
    Shen et al.
    Oncogene, 2008;27:6571
  4. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
    Stuber et al.
    Mol.Cancer, 2009;8:23
  5. PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis.
    Bykov et al.
    Oncogene, 2005;24:3484

Product Datasheets

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Citations for PRIMA-1MET

The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1MET include:

3 Citations: Showing 1 - 3

  1. Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype.
    Authors: Katja Et al.
    Mol Cancer Ther  2022;21:1236-1245
  2. Estrogen Receptor-Beta2 (ERβ2)-Mutant p53-FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC).
    Authors: Kunle O Et al.
    Cancers (Basel)  2022;14
  3. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

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