PRIMA-1
Discontinued Product
Chemical Name: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Purity: ≥99%
Biological Activity
PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound.
Bykov et al.
Nat.Med., 2002;8:282 -
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.
Bykov et al.
Carcinogenesis, 2002;23:2011 -
PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax.
Wang et al.
Biochem.Biophys.Res.Commun., 2007;352:203
Product Datasheets
Citations for PRIMA-1
The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1 include:
3 Citations: Showing 1 - 3
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An inverse docking approach for identifying new potential anti-cancer targets.
Authors: Grinter Et al.
J Neurosci 2011;29:795
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Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study.
Authors: Benakanakere Et al.
Endocr Relat Cancer 2009;16:85
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Sequential transcription factor targeting for diffuse large B-cell lymphomas.
Authors: Cerchietti Et al.
Cancer Res 2008;68:3361
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