Pioglitazone hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Peroxisome proliferator-activated receptor ? agonist suppresses mast cell maturation and induces apoptosis
   Y Zhang, X Li, S Fang, Z Zhu, M Yao, L Ying, L Zhu, Z Ma, W Wang
   Mol Med Rep, 2017;0(0):.
2. Effects of the peroxisome proliferator-activated receptor (PPAR)-delta agonist GW501516 on bone and muscle in ovariectomized rats.
   Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, Eriksen E, Syversen U
   Endocrinology, 2014;155(6):2178-89.
3. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs.
   Helmy M, Helmy M, El-Mas M
   PLoS ONE, 2015;10(11):e0142303.
4. Cultured Human Periosteum-Derived Cells Can Differentiate into Osteoblasts in a Perioxisome Proliferator-Activated Receptor Gamma-Mediated Fashion via Bone Morphogenetic Protein signaling
   
   Int J Med Sci, 2016;13(11):806-818.
5. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones.
   Willson et al.
   J.Med.Chem., 1996;39:665
6. Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as Ins sensitizers with antidiabetic activities.
   Momose et al.
   J.Med.Chem., 2002;45:1518
7. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglit.
   Sakamoto et al.
   Biochem.Biophys.Res.Commun., 2000;278:704
8. The synergistic enhancement of cloning efficiency in individualized human pluripotent stem cells by peroxisome proliferative-activated receptor-γ (PPARγ) activation and Rho-associated kinase (ROCK) inhibition.
   Kajabadi et al.
   J.Biol.Chem., 2015;290:26303

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