PARPi-FL
Chemical Name: (T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron
Purity: ≥90%
Biological Activity
PARPi-FL is a fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.Optical Data for PARPi-FL
| Emission Color | Green |
|---|---|
| λabs | 502 nm |
| λem | 510 nm |
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Quantitating drug-target engagement in single cells in vitro and in vivo.
Dubach et al.
Nat.Chem.Biol., 2017;13:168 -
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Thurber et al.
Nat.Commun., 2013;4:1504 -
Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors.
Thurber et al.
Mol.Cancer Ther., 2014;13:986
Product Datasheets
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