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Olaparib

Catalog #: 7579
1 Citation Datasheet
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7579/50
Olaparib | CAS No. 763113-22-0 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: Potent PARP inhibitor

Chemical Name: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.

Technical Data

M.Wt:
434.47
Formula:
C24H23FN4O3
Solubility:
Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
763113-22-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Citation for Olaparib

The citations listed below are publications that use Tocris products. Selected citations for Olaparib include:

1 Citation: Showing 1 - 1

  1. Sequential Targeting of PLK1 and PARP1 Reverses the Resistance to PARP Inhibitors and Enhances Platin-Based Chemotherapy in BRCA-Deficient High-Grade Serous Ovarian Cancer with KRAS Amplification.
    Authors: Monika Et al.
    Int J Mol Sci  2022;23

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