NSC 617145
Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Purity: ≥98%
Biological Activity
NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Aggarwal et al.
Cancer Res., 2013;73:5497 -
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.
Aggarwal et al.
Cell Cycle, 2013;12:3329
Product Datasheets
Citation for NSC 617145
The citations listed below are publications that use Tocris products. Selected citations for NSC 617145 include:
1 Citation: Showing 1 - 1
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WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.
Authors: Robert H Et al.
Nat Commun 2021;12:6561
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