NLS-StAx-h

Catalog #: 6531 Datasheet

Catalog #	Availability	Size / Price	Qty
6531/100U

1 Image

Description: Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions

Purity: ≥95%

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Product Details

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Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

NLS-StAx-h is a Wnt inhibitor (IC₅₀ = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

Technical Data

M.Wt:

3445.26

Formula:

C₁₆₁H₂₇₅N₅₅O₂₉

Sequence:

PKKKRKVRRWPRXILDXHVRRVWR

(Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

2872559-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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