NDT 30805
Chemical Name: 2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione
Purity: ≥95%
Biological Activity
NDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC50 values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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