Nigericin sodium salt
Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
Biological Activity
Nigericin sodium salt is a potassium ionophore; it exchanges K+ for H+ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy
MG Khalafalla, LT Woods, JM Camden, AA Khan, KH Limesand, MJ Petris, L Erb, GA Weisman
J. Biol. Chem., 2017;0(0):. -
Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production
H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee
Sci Rep, 2017;7(1):1314. -
The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin.
Hamidinia et al.
Biochemistry., 2004;43:15956 -
Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles.
Eytan et al.
J.Biol.Chem., 1990;22:12949
Product Datasheets
Citations for Nigericin sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Nigericin sodium salt include:
19 Citations: Showing 1 - 10
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IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.
Authors: Yuanyuan Et al.
Cell Death Dis 2023;14:103
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Pharmacological inhibition of HDAC6 suppresses xNLRP3 inflammasome-mediated IL-1β release.
Authors: Bockstiegel Et al.
Biochem Pharmacol 2023;
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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Authors: Songyan Et al.
Commun Biol 2022;5:47
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Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs.
Authors: Didier Et al.
MBio 2022;13:e0117822
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Single-cell lactate production rate as a measure of glycolysis in endothelial cells.
Authors: Jun Et al.
STAR Protoc 2021;2:100807
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Selective activation of PFKL suppresses the phagocytic oxidative burst.
Authors: Matthew Et al.
Cell 2021;184:4480-4494.e15
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Spatiotemporal Quantification of Cytosolic pH in Arabidopsis Pollen Tubes.
Authors: José A Et al.
Bio Protoc 2021;11:e4084
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NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation.
Authors: Jeongho Et al.
Cells 2021;10
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Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity
Authors: Krzesniak Et al.
Cell Signal 2020;69
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Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation.
Authors: Bao-Xue Et al.
J Cell Mol Med 2020;24:12716-12725
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LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.
Authors: Alison Et al.
Autophagy 2020;16:1314-1331
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Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.
Authors: Ahn Et al.
Sci Rep 2018;8:13659
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Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.
Authors: Platnich Et al.
Cell Rep 2018;25:1525
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A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome.
Authors: Kun Et al.
Cell Rep 2018;24:2356-2369.e5
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Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
Authors: Roche Et al.
J Cell Biol 2018;217:3560
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Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.
Authors: Ahn Et al.
Sci Rep 2017;7:1314
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Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation.
Authors: Ahn Et al.
Sci Rep 2017;7:12409
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Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome.
Authors: Han Et al.
J Ginseng Res 2017;41:513
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Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome
Authors: Lee Et al.
Cellular Immunology 2016;306-307:53
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