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NCT 02

Catalog #: 7551 Datasheet
Catalog # Availability Size / Price Qty
7551/10
7551/50
NCT 02 | CAS No. 790245-61-3 | Molecular Glues
1 Image
Description: Molecular glue; induces degradation of CCNK and CDK12

Chemical Name: 6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide

Purity: ≥98%

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Biological Activity

NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC50 ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.

Technical Data

M.Wt:
312.39
Formula:
C17H16N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
790245-61-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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