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NBC 6

Catalog #: 6925 Datasheet
Catalog # Availability Size / Price Qty
6925/50
6925/10
NBC 6 | CAS No. 2068818-02-8 | Inflammasomes Inhibitors
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Description: NLRP3 inflammasome inhibitor

Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Technical Data

M.Wt:
409.5
Formula:
C18H16BCl3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2068818-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Manchester.

Background References

  1. Boron-based inhibitors of the NLRP3 inflammasome.
    Baldwin et al.
    Cell Chem.Biol., 2017;24:1321

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