ML 385
Chemical Name: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
Purity: ≥98%
Biological Activity
ML 385 is an Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors.
Singh et al.
ACS Chem.Biol., 2016;11:3214
Product Datasheets
Citations for ML 385
The citations listed below are publications that use Tocris products. Selected citations for ML 385 include:
2 Citations: Showing 1 - 2
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Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging.
Authors: Steven C Et al.
Acta Neuropathol Commun 2023;11:6
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Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats.
Authors: Jeong Hwan Et al.
Nutrients 2020;12
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Used to inhibit nrf2
