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(-)-JQ1

Catalog #: 5603
2 Citations Datasheet
Catalog # Availability Size / Price Qty
5603/10
(-)-JQ1 | CAS No. 1268524-71-5 | Bromodomain Inhibitors
1 Image
Description: Negative control for (+)-JQ1

Chemical Name: (6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(-)-JQ1 is an inactive control for (+)-JQ1. Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.

Active Enantiomer also available.

Technical Data

M.Wt:
456.99
Formula:
C23H25ClN4O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1268524-71-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (+)-JQ1 probe summary on the SGC website.
Other Product-Specific Information:

Background References

  1. Selective inhibition of BET bromodomains.
    Filippakopoulos et al.
    Nature, 2010;468:1067

Product Datasheets

Citations for (-)-JQ1

The citations listed below are publications that use Tocris products. Selected citations for (-)-JQ1 include:

2 Citations: Showing 1 - 2

  1. BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response.
    Authors: Andrieu Et al.
    Cancer Lett  2019;465:45
  2. BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle.
    Authors: Perry Et al.
    Scientific Reports  2015;290:9111

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