Memantine hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
   Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, Luhder F, Schuler T, Schraven B, Heine M, Bommhardt U
   Cell Commun Signal, 2014;12(0):75.
2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
3. Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.
   Brison E, Jacomy H, Desforges M, Talbot P
   J Virol, 2014;88(3):1548-63.
4. Neuroprotective concentrations of the N-MthD.-aspartate open-channel blocker Mem. are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.
   Chen et al.
   Neuroscience, 1998;86:1121
5. Mem.: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse.
   Parsons et al.
   Neuropharmacology, 2007;53:699
6. Mem. is a clinically well tolerated N-MthD.-aspartate (NMDA) receptor antagonist - a review of preclinical data.
   Parsons et al.
   Neuropharmacology, 1999;38:735
7. Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.
   Zajaczkowski et al.
   Neuropharmacology, 1997;36:961

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