BDNF (human)
Purity: ≥95%
Biological Activity
BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. BDNF enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. In an animal model of Huntington's disease, BDNF administration or overexpression rescues the disease phenotype.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity.
Lipsky and Marini
Ann.N.Y.Acad.Sci., 2007;1122:130 -
Neurotrophic factors as a therapeutic target for Parkinson's disease.
Evans and Barker
Expert Opin.Ther.Targets, 2008;12:437
Product Datasheets
Citations for BDNF (human)
The citations listed below are publications that use Tocris products. Selected citations for BDNF (human) include:
6 Citations: Showing 1 - 6
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LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Authors: Hashimotodani Et al.
Neuron 2017;95:928
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BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
Mol Pain 2015;35:4469
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Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.
Authors: Parsons Et al.
J Biol Chem 2014;289:3518
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Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.
Authors: Li Et al.
PLoS One 2011;6:e26065
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Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin.
Authors: Hossaini Et al.
Cell Metab 2010;6:43
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Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.
Authors: Chiara Et al.
J Neurosci 2010;30:8127
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