LDN 193189 in solution New

Biological Activity

LDN 193189 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of LDN 193189 pre-dissolved in water. A potent and selective ALK2 and ALK3 inhibitor (IC₅₀ values are 5 nM and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. BMP type I receptor inhibition reduces heterotopic ossification.
   Yu et al.
   Nat.Med., 2008;14:1363
2. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.
   Chambers et al.
   Nat.Biotechnol., 2012;30:715
3. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
   Cuny et al.
   Bioorg.Med.Chem.Lett., 2008;18:4388
4. Chemical approaches to stem cell biology and therapeutics.
   Li et al.
   Cell Stem Cell, 2013;13:270
5. Generation of cerebral organoids from human pluripotent stem cells.
   Lancaster et al.
   Nat.Protoc., 2015;9:2329

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