SU 5402

Biological Activity

For more information about how SU 5402 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium.
   Dalle Nogare D, Somers K, Rao S, Matsuda M, Reichman-Fried M, Raz E, Chitnis A
   Development, 2014;141(16):3188-96.
2. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells
   AR Rodrigues, N Yakushiji-, Y Atsuta, G Andrey, P Schorderet, D Duboule, CJ Tabin
   Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
3. Fibroblast Growth Factor 2 Modulates Hippocampal Microglia Activation in a Neuroinflammation Induced Model of Depression
   MM Tang, WJ Lin, YQ Pan, YC Li
   Front Cell Neurosci, 2018;12(0):255.
4. FGF2 and insulin signaling converge to regulate cyclin D expression in multipotent neural stem cells.
   Adepoju A, Micali N, Ogawa K, Hoeppner D, McKay R
   Stem Cells, 2014;32(3):770-8.
5. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF.
   Yang, Fan, Liu, Yunhui, Tu, Jie, Wan, Jun, Zhang, Jie, Wu, Bifeng, Chen, Shanping, Zhou, Jiawei, Mu, Yangling, Wang, Liping
   Nat Commun, 2014;5(0):5627.
6. Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
   
   Nat Commun, 2016;7(0):13463.
7. Neural stem cell differentiation is mediated by integrin beta4 in vitro.
   Su et al.
   Int.J.Biochem.Cell Biol., 2009;41:916
8. Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases.
   Sun et al.
   J.Med.Chem., 1999;42:5120
9. Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma.
   Paterson et al.
   Br.J.Haematol., 2004;124:595
10. FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.
    Tanaka et al.
    Nature, 2005;435:172
11. Capture of authentic embryonic stem cells from rat blastocysts.
    Buehr et al.
    Cell, 2008;135:1287
12. Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
    M Igoillo-Es, AF Oliveira, C Cosentino, F Fantuzzi, C Demarez, S Toivonen, A Hu, S Chintawar, M Lopes, N Pachera, Y Cai, B Abdulkarim, M Rai, L Marselli, P Marchetti, M Tariq, JC Jonas, M Boscolo, M Pandolfo, DL Eizirik, M Cnop
    JCI Insight, 2019;0(0):.

Product Datasheets