Lamotrigine
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Purity: ≥99%
Biological Activity
Lamotrigine is an anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels.Water-soluble Salt also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture.
Zona and Avoli
Epilepsia, 1997;38:522 -
Modulation of calcium and potassium currents by lamotr.
Grunze et al.
Neuropsychobiology, 1998;38:131 -
Neurochemical and behavioral aspects of lamotr.
Leach et al.
Epilepsia, 1991;32:S4 -
The anticonvulsive drug lamotr. blocks neuronal α4β2 nicotinic acetylcholine receptors.
Zheng et al.
J.Pharmacol.Exp.Ther., 2010;335:401
Product Datasheets
Citations for Lamotrigine
The citations listed below are publications that use Tocris products. Selected citations for Lamotrigine include:
2 Citations: Showing 1 - 2
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Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.
Authors: Lazar Et al.
Front Pharmacol 2015;6:210
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Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
Authors: Kashyap Et al.
J Neurosci 2015;2
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