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JP-2-196

Catalog #: 8046 Datasheet
Catalog # Availability Size / Price Qty
8046/50
JP-2-196 | Molecular Glues
1 Image
Description: RNF126 chemical handle

Chemical Name: 1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione hydrochloride

Purity: ≥95%

Product Details
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Biological Activity

JP-2-196 is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM. By facilitating E3 ligase recruitment, JP-2-196 induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
310.78
Formula:
C15H18N2O3.HCl
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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