IHR-Cy3
Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Purity: ≥95%
Biological Activity
IHR-Cy3 is a potent fluorescent Smo antagonist (IC50 = 100 nM).Non-fluorescent analog also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
Fan et al.
Chem.Biol., 2014;21:1680
Product Datasheets
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