IHR 1

Catalog #: 5554 Datasheet

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5554/10
5554/50

IHR 1 | CAS No. 548779-60-8 | Smoothened Receptor Antagonists

1 Image

Description: Potent Smo antagonist

Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]

Purity: ≥99%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

IHR 1 is a potent Smo antagonist (IC₅₀ = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Fluorescent Analog also available.

Technical Data

M.Wt:

454.13

Formula:

C₂₀H₁₂Cl₄N₂O₂

Solubility:

Soluble to 20 mM in DMSO with gentle warming

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

548779-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Fluorescent Analog Available

Background References

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
Fan et al.
Chem.Biol., 2014;21:1680

Product Datasheets

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