Home / Bromodomain Inhibitors / I-BRD9

I-BRD9

Catalog #: 5591
5 Citations Datasheet
Catalog # Availability Size / Price Qty
5591/10
5591/50
I-BRD9 | CAS No. 1714146-59-4 | Bromodomain Inhibitors
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Description: Potent and selective BRD9 inhibitor

Chemical Name: 5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

I-BRD9 is a potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. Downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-BRD9 is reviewed on the chemical probes website.

Technical Data

M.Wt:
497.55
Formula:
C22H22F3N3O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1714146-59-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-BRD9 probe summary on the SGC website.

Product Datasheets

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Citations for I-BRD9

The citations listed below are publications that use Tocris products. Selected citations for I-BRD9 include:

5 Citations: Showing 1 - 5

  1. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism.
    Authors: Yili Et al.
    Nat Commun  2023;14:1413
  2. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4.
    Authors: Nasun Et al.
    Proc Natl Acad Sci U S A  2022;119
  3. The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.
    Authors: Yong Et al.
    Nat Commun  2020;11:2639
  4. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.
    Authors: Brien Et al.
    Elife  2018;7:e41305
  5. Vitamin D switches BAF complexes to protect β cells.
    Authors: Wei Et al.
    Cell  2018;173:1135

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