Human Fatty Acid Synthase/FASN Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Fatty Acid Synthase/FASN

FASN (Fatty Acid SyNthase; also FAS) is a cytosolic member of the short chain dehydrogenase/reductase family 27X. It is expressed in neurons, skeletal muscle, adipocytes and hepatocytes and both catalyzes the formation of palmitic acid from acetylCoA and malonylCoA and likely mediates the transfer of fatty acids to peptides. Human FASN is 2511 amino acids (aa) in length. It contains multiple domains, including a beta ‑ketoacyl synthase domain (aa 1‑414), an acyl and malonyl transferase domain (aa 429‑817), an enoyl reductase domain (aa 1563‑1863), a beta ‑ketoacyl reductase domain (aa 1864‑2118) and a thioesterase domain (aa 2207‑2511). FASN exists as an antiparallel homodimer. There is one theoretical alternative start site at Met2073. Over aa 10‑212, human FASN shares 92% aa identity with mouse FASN.

Product Datasheets

Related Research Areas

• Lipid/Cholesterol Metabolism Enzymes