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Forskolin

Catalog #: 1099
86 Citations Datasheet
Catalog # Availability Size / Price Qty
1099/10
1099/50
Forskolin | CAS No. 66575-29-9 | Adenylyl Cyclase Activators
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Description: Adenylyl cyclase activator

Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

Purity: ≥98%

Product Details
Citations (86)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC50 = 0.5 μM). In combination with 5 other compounds, forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors: Valproic acid, sodium salt (Cat. No. 2815), RepSox (Cat. No. 3742), Tranylcypromine hydrochloride (Cat. No. 3852), CHIR 99021 (Cat. No. 4423) and 3-Deazaneplanocin A hydrochloride (Cat. No. 4703). In combination with IBMX (Cat. No. 2845), forskolin induces neural differentiation of mesenchymal stem cells by downregulating neuron restrictive silencer factor. In a rat model of Huntington's disease-like neurodegeneration, forskolin also exhibits neuroprotective effects. Hypotensive and vasodilatory agent.

Water-soluble analog, NKH 477 (Cat. No. 1603), and Forskolin synthesized to Ancillary Material Grade also available.

For more information about how Forskolin may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.

Technical Data

M.Wt:
410.51
Formula:
C22H34O7
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
66575-29-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

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  4. Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
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    J Cell Mol Med, 2015;19(1):210-26.
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    Belgacem Y, Borodinsky L
    Proc Natl Acad Sci U S A, 2015;112(13):4140-5.
  16. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.
    Moon C, Zhang W, Ren A, Arora K, Sinha C, Yarlagadda S, Woodrooffe K, Schuetz J, Valasani K, de Jonge H, Shanmukhappa S, Shata M, Buddington R, Parthasarathi K, Naren A
    J Biol Chem, 2015;290(18):11246-57.
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    D Hendriks, B Artegiani, H Hu, S Chuva de S, H Clevers
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  27. Forskolin carbamates: binding and activation studies with type I adenylyl cyclase.
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Product Datasheets

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Citations for Forskolin

The citations listed below are publications that use Tocris products. Selected citations for Forskolin include:

86 Citations: Showing 1 - 10

  1. Snake venom gland organoids
    Authors: Post Et al.
    Cell  2020;180:233
  2. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells.
    Authors: Delpiano Et al.
    Front Pharmacol  2019;9:1462
  3. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
    Authors: Schnúr Et al.
    Sci Rep  2019;9:12706
  4. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
    Authors: Jewell Et al.
    Elife  2019;8
  5. Dual-Mode FRET and BRET Sensors for Detecting cAMP Dynamics.
    Authors: French Et al.
    ACS Omega  2019;4:15504
  6. Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression.
    Authors: Cordonier Et al.
    J Endocr Soc  2019;3:1246
  7. Long-term expanding human airway organoids for disease modeling.
    Authors: Sachs Et al.
    EMBO J  2019;38
  8. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
    Authors: Chiu Et al.
    Cell Rep  2019;28:332
  9. Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.
    Authors: Saito Et al.
    Cell Rep  2019;27:1265
  10. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.
    Authors: Franchini Et al.
    iScience  2019;19:927
  11. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  12. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
    Authors: Segal Et al.
    Nat Commun  2019;10:3350
  13. DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
    Authors: Tozzi Et al.
    Cell Death Dis  2018;9(2):204
  14. Downregulation of p53 drives autophagy during human trophoblast differentiation.
    Authors: Gauster Et al.
    Cell Mol Life Sci  2018;75:1839
  15. A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
    Authors: Ford Et al.
    Dev Cell  2018;47:509
  16. MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons.
    Authors: Mo Et al.
    J Neurosci  2018;38:9883
  17. CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
    Authors: Liu Et al.
    Cell Stem Cell.  2018;22:252
  18. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
    Authors: Patra Et al.
    Nat Cell Biol  2018;20:811
  19. Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR.
    Authors: Noh Et al.
    Autophagy  2018;14:1761
  20. Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.
    Authors: Costa Et al.
    Front Mol Neurosci  2018;11:353
  21. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
    Authors: Burdyga Et al.
    Proc Natl Acad Sci U S A.  2018;115(28):E6497
  22. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
    Authors: Li Et al.
    Theranostics  2017;7:4671
  23. Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM.
    Authors: Demeautis Et al.
    Sci Rep  2017;7:41026
  24. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  25. A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.
    Authors: Burgueño Et al.
    Sci Rep  2017;7:15389
  26. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
    Authors: Al-Taei Et al.
    Oncoimmunology  2017;6:e1268308
  27. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  28. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports  2016;6:32602
  29. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of Ins signaling in an Alzheimer's disease mouse model.
    Authors: Chan Et al.
    Cell  2016;6:26119
  30. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
    Authors: Havekes Et al.
    J Neurosci  2016;36:8936
  31. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.
    Authors: Pattabiraman Et al.
    Science  2016;351:aad3680
  32. A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress.
    Authors: Aguileta Et al.
    Cell Death Differ  2016;23:1670
  33. New functional activity of aripipr. revealed: Robust antagonism of D2 DA receptor-stimulated Gβγ signaling.
    Authors: Brust Et al.
    Cell Rep  2015;93:85
  34. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secr. Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform.
    Authors: Emery Et al.
    J Cell Mol Med  2015;87:928
  35. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Sci Rep  2015;6:e1629
  36. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Eneuro  2015;6:8480
  37. The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.
    Authors: Ang Et al.
    Ann Clin Transl Neurol  2015;5:8134
  38. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice.
    Authors: Li Et al.
    Mol Pharmacol  2015;4:246
  39. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
    Authors: Broadbent Et al.
    Sci Rep  2015;467:1783
  40. Retroactive modulation of spike timing-dependent plasticity by DA.
    Authors: Brzosko Et al.
    Elife  2015;4
  41. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Biochem Pharmacol  2015;3:e00159
  42. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Pharmacol Res Perspect  2015;35:621
  43. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    Biochim Biophys Acta  2015;35:11315
  44. Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab  2015;308:E130
  45. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
    Authors: Walker Et al.
    Nat Commun  2015;2:595
  46. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.
    Authors: Moon Et al.
    J Biol Chem  2015;290:11246
  47. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  48. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Stem Cell Reports  2015;19:210
  49. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Mol Metab  2015;1853:1749
  50. Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
    Authors: Cooke Et al.
    Cell Death Dis  2015;172:593
  51. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    Pflugers Arch  2015;12:396
  52. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
    Authors: Belgacem and Borodinsky
    Eur J Neurosci  2015;112:4140
  53. Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
    Authors: Chou Et al.
    PLoS One  2014;9:e99432
  54. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol  2014;91:369
  55. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
    Authors: Yang Et al.
    J Biol Chem  2014;66:83
  56. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
    Authors: Felizola Et al.
    Glia  2014;52:159
  57. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton Et al.
    Br J Pharmacol  2014;3:516
  58. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence.
    Authors: Muthusamy Et al.
    Stem Cell Reports  2014;3:169
  59. Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.
    Authors: Waheed Et al.
    Br J Pharmacol  2014;171:2659
  60. The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation.
    Authors: Vandame Et al.
    Cell Cycle  2014;13:3232
  61. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Br J Pharmacol  2013;8:e71441
  62. Prostaglandin E receptor EP1 forms a complex with DA D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
    Authors: Ehrlich Et al.
    Mol Pharmacol  2013;84:476
  63. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
    Authors: Wiseman Et al.
    J Biol Chem  2013;288:17803
  64. Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties.
    Authors: Pale Et al.
    Neuroscience  2013;245:74
  65. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  66. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
    Authors: Sohn Et al.
    J Mol Endocrinol  2013;152:612
  67. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
    Authors: Korboukh Et al.
    J Med Chem  2012;55:6467
  68. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  69. DArgic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    J Neurosci  2012;35:507
  70. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    J Neurosci  2012;32:3992
  71. AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
    Authors: Bolognini Et al.
    Br J Pharmacol  2012;165:2561
  72. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury.
    Authors: Horváth Et al.
    J Neurosci  2012;165:2462
  73. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
    Authors: Mitra Et al.
    Nat Neurosci  2012;15:250
  74. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
    Authors: Tran Et al.
    Assay Drug Dev Technol  2012;10:37
  75. Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells.
    Authors: Althaus Et al.
    Am J Respir Cell Mol Biol  2011;44:53
  76. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.
    Authors: Benito Et al.
    J Neurosci  2011;31:18237
  77. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.
    Authors: Chen Et al.
    J Biol Chem  2011;286:13502
  78. Mouse embryonic retina delivers information controlling cortical neurogenesis.
    Authors: Bonetti and Surace
    J Mol Cell Cardiol  2010;5:e15211
  79. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  80. DA-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    PLoS One  2010;30:2935
  81. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    J Neurosci  2010;30:12733
  82. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci  2010;11:7
  83. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
    Authors: Byrnes Et al.
    J Clin Invest  2009;57:550
  84. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Authors: Roscioni Et al.
    Respir Res  2009;10:88
  85. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    Authors: Rao Et al.
    PLoS One  2007;117:4022
  86. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Biol Chem  2002;277:31459

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